The short version of epithalamin fits in a sentence. The long version — which is the one that helps — is below.
This page was last updated on 2026-01-10 and is reviewed periodically as new material appears.
Laboratory work has examined effects on telomerase activity in cultured cells, on melatonin rhythms in animals, and on markers of oxidative stress. Some experiments report measurable changes while others show none, and the reported findings rest largely on small studies. The absence of large independent trials means the generality of these results is unresolved rather than settled. Review articles occasionally apply the label geroprotector, a term that reflects a research hypothesis about ageing rather than an established clinical finding.
Epitalon is the common name for a synthetic tetrapeptide with the sequence alanine-glutamate-aspartate-glycine, usually abbreviated AEDG. All four residues are proteinogenic amino acids, and the free peptide has a calculated mass near 390 grams per mole. Because the chain is short and carries no modifications, it is assembled readily by solid-phase synthesis and is distributed mainly as a freeze-dried solid for laboratory work. Catalogue listings use the spellings epitalon, epithalone, and simply AEDG, and the three refer to the same sequence.
The compound is generally presented as a synthetic fragment of epithalamin, a pineal gland extract investigated in the former Soviet Union from the 1970s onward. Vladimir Khavinson and colleagues in Saint Petersburg developed short peptides modelled on such extracts, and epitalon became the most widely cited of those sequences. Most primary reports appeared in Russian-language journals or in proceedings with limited international circulation. Independent replication in laboratories outside that network remains sparse, and much repeated secondary material traces back to a small number of originating groups.
The most frequently cited proposed action is induction of telomerase, the enzyme that adds repeat sequences to chromosome ends. Cell-culture work from the originating group reported higher telomerase reverse transcriptase expression and measurable telomere elongation in human somatic cells after exposure. How a four-residue peptide would reach nuclear gene regulation is not established, and no cell-surface receptor or uptake route has been identified. Additional reports describe changes in melatonin secretion, antioxidant enzyme activity and lipid peroxidation in aged animals, but these findings remain mechanistically unconnected to the telomerase observation.
Published evidence comes mainly from Russian-language journals and from a single research group, with small sample sizes and limited independent replication. A few laboratories outside that group have examined related peptides and reported weaker or absent telomerase effects, so the central claim is best described as contested rather than settled. Rodent studies report modest changes in some ageing markers and in survival, but designs vary and control conditions are often sparse. No large randomised trial in humans has been published, and long-term safety data in healthy populations are correspondingly thin.
| Property | Value | Notes |
|---|---|---|
| Molecular formula | C14H22N4O9 | Computed for the free acid of Ala-Glu-Asp-Gly |
| Molecular mass | About 390.35 g/mol | Free peptide; salt forms shift the value |
| Appearance | White to off-white solid | Typical of short peptides after freeze-drying |
| Solubility class | Freely soluble in water | Aqueous buffers are also commonly used |
| Common synonyms | Epitalon, epithalone, AEDG | AEDG is the single-letter sequence |
In early March 1803, the Addington ministry received word that Cape Colony had been reoccupied by the British army, in accordance with the orders which had subsequently been countermanded. On 8 March they ordered military preparations to guard against possible French retaliation and justified them by claiming that it was only in response to French preparations and that they were conducting serious negotiations with France. In a few days, it was known that Cape Colony had been handed over in accordance with the counter-orders, but it was too late. Bonaparte berated the British ambassador Lord Whitworth in front of 200 spectators over the military preparations. The Addington ministry realised they would face an inquiry over their reasons for the military preparations, and during April unsuccessfully attempted to secure the support of William Pitt to shield them from damage. In the same month, the ministry issued an ultimatum to France, demanding a retention of Malta for at least ten years, the permanent acquisition of the island of Lampedusa from the Kingdom of Sicily, and the evacuation of Holland. They also offered to recognise French gains in Italy if they evacuated Switzerland and compensated the Kingdom of Sardinia for his territorial losses. France offered to place Malta in the hands of Russia to satisfy British concerns, pull out of Holland when Malta was evacuated, and form a convention to give satisfaction to Britain on other issues. The Addington ministry denied that Russia had made an offer, and Whitworth left Paris.
Korea is believed to be the first country in Asia that acupuncture spread to outside of China. Within Korea there is a legend that acupuncture was developed by emperor Dangun, though it is more likely to have been brought into Korea from a Chinese colonial prefecture in 514 AD. Acupuncture use was commonplace in Korea by the 6th century. It spread to Vietnam in the 8th and 9th centuries. As Vietnam began trading with Japan and China around the 9th century, it was influenced by their acupuncture practices as well. China and Korea sent "medical missionaries" that spread traditional Chinese medicine to Japan, starting around 219 AD. In 553, several Korean and Chinese citizens were appointed to re-organize medical education in Japan and they incorporated acupuncture as part of that system. Japan later sent students back to China and established acupuncture as one of five divisions of the Chinese State Medical Administration System. Acupuncture began to spread to Europe in the second half of the 17th century. Around this time, Willem ten Rhijne, a physician working for the Dutch East India Company, met Japanese acupuncture practitioners and later encouraged Europeans to further investigate it. He published the first in-depth description of acupuncture for the European audience and created the term "acupuncture" in his 1683 work De Acupunctura. France was an early adopter among the West due to the influence of Jesuit missionaries, who brought the practice to French clinics in the 16th century.
The ÄKTA explorer was the first high end FPLC (Fast Protein Liquid Chromatography) system that was developed for Life Science research by the Swedish company Pharmacia in 1994. Its purpose was to simplify and automatize protein purification. It was followed by a line of similar devices (the "Äkta" line). The product line name was transferred together with the sale of Pharmacia first to Amersham and then to GE Healthcare. Although protein purification is possible with a large range of chromatographic devices, the Äkta line represents together with BioRad's NGC line the only devices that were specifically designed for this purpose both from the hardware and software perspective. Main users of these devices are the pharmaceutical industry and academic researchers.
== Life == Kleinman received a B.S. in chemistry from Simmons College in 1969 and a M.S. and Ph.D. from the Massachusetts Institute of Technology in 1973. She did postdoctoral training at Tufts University. Kleinman worked at National Institutes of Health (NIH) from 1975 to 2006 in the National Institute of Dental and Craniofacial Research (NIDCR) and served as Chief of the Cell Biology Section in NIDCR's Laboratory of Cell and Developmental Biology (1985–2006). Her laboratory was the first to report the wound-healing effects of thymosin beta 4 (TB4), a synthetic version of a naturally occurring molecule. Her research accomplishments also include defining various angiogenic and antiangiogenic molecules and identifying sites on laminin for adhesion, migration, neurite outgrowth, angiogenesis, metastases and inhibition of metastases, and the respective receptors. Kleinman is a co-inventor of Matrigel. In 1992, during his first week as deputy director for intramural research, Lance Liotta appointed Kleinman to chair the new intramural women scientists' task force to investigate impediments to the advancement of women at NIH. She has received numerous awards for her research and for her efforts on behalf of women scientists. She has obtained multiple patents, many of which have been commercialized and one of which is in pivotal clinical trials. In 2006, she left the NIH to join the George Washington University as an adjunct professor in the department of biochemistry and molecular biology. She has subsequently consulted for various pharmaceutical companies Kleinman is Jewish.
Sources: en.wikipedia.org
== Relations == The attached or orbital margins are connected to the circumference of the orbit by the orbital septum. The lateral angles are attached to the zygomatic bone by the lateral palpebral raphe. The medial angles of the two plates end at the lacrimal lake, and are attached to the frontal process of the maxilla by the medial palpebral ligament). The sulcus subtarsalis is a groove in the inner surface of each eyelid. Along the inner margin of the tarsus are modified sebaceous glands known as tarsal glands (or meibomian glands), aligned vertically within the tarsi: 30 to 40 glands in the upper lid, and 20 to 30 in the lower lid, which secrete a lipid-rich product which helps keep the lacrimal secretions or tears from evaporating too quickly, thus keeping the eye moist.
=== Conversion to other biologically active amines === The histidine amino acid is a precursor for histamine, an amine produced in the body necessary for inflammation. The enzyme histidine ammonia-lyase converts histidine into ammonia and urocanic acid. A deficiency in this enzyme is present in the rare metabolic disorder histidinemia, producing urocanic aciduria as a key diagnostic finding. Histidine can be converted to 3-methylhistidine, which serves as a biomarker for skeletal muscle damage, by certain methyltransferase enzymes. Histidine is also a precursor for carnosine biosynthesis, which is a dipeptide found in skeletal muscle. In Actinomycetota and filamentous fungi, such as Neurospora crassa, histidine can be converted into the antioxidant ergothioneine.
These increases are partially related to the COVID-19 pandemic, which continues to highlight the weaknesses of current food and health systems. It has contributed to food insecurity, increasing hunger worldwide; meanwhile, lower physical activity during lockdowns has contributed to increases in overweight and obesity. In 2020, experts estimated that by the end of the year, the pandemic could have double the number of people at risk of suffering acute hunger, around 130 million more undernourished people. Similarly, experts estimated that the prevalence of moderate and severe wasting could increase by 14% due to COVID-19; coupled with reductions in nutrition and health services coverage, this could result in over 128,000 additional deaths among children under 5 in 2020 alone. Although COVID-19 is less severe in children than in adults, the risk of severe disease increases with undernutrition. Other major causes of hunger include manmade conflicts, climate changes, and economic downturns.
What survived amounts to only 29 articles. An ambiguous wording in the latest guide to the Paris Archives suggests that many registers were preserved. For example, it mentions a register from Saint-Eustache covering the period 1529–1748, even though this parish originally had 395 registers dating from 1529 to 1789. The mentioned registers are collections of excerpts compiled by Abraham Charles Guiblet. They pertain to noble or notable individuals and may be very brief, sometimes indicating only the name of a godparent or witness. These are preserved in the Manuscripts Department of the Bibliothèque nationale de France. Some have been digitized:
Some later variants were more infectious. The virus is airborne and primarily spreads between people through close contact and via aerosols and respiratory droplets that are exhaled when talking, breathing, or otherwise exhaling, as well as those produced from coughs and sneezes. It enters human cells by binding to angiotensin-converting enzyme 2 (ACE2), a membrane protein that regulates the renin–angiotensin system.
Sources: en.wikipedia.org
It is a four-amino-acid peptide with the sequence alanine-glutamate-aspartate-glycine. The chain is unmodified and contains only standard proteinogenic residues, which makes it straightforward to produce by solid-phase synthesis and to characterise by standard peptide methods.
Epitalon and epithalon both circulate, and the difference reflects transliteration of a name coined in Russian-language publications. Reference to the extract it derives from, epithalamin, explains the shared stem. Databases and suppliers are inconsistent, so a search for one spelling alone may miss relevant entries.
No. Epithalamin is a multi-component preparation obtained from pineal tissue, and its exact composition is not fully characterised. Epitalon is a single defined tetrapeptide described as a short synthetic counterpart of that extract, so the two are related in origin but not interchangeable in identity.
No. Epithalamin is a peptide-containing extract of bovine pineal glands, while epitalon is a single synthetic tetrapeptide. The extract contains many peptides and other tissue components, so its composition varies between batches in ways that a synthesised sequence does not.